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Rev. invest. clín ; 54(4): 342-348, jul.-ago. 2002.
Article in Spanish | LILACS | ID: lil-332904

ABSTRACT

The telomerase is a ribonucleoprotein enzyme to which multiple functions have been attributed, the most important of these is the maintenance of the telomere which is related with cellular immortalization and cancer. 85 of human tumors have telomerase activity, that in normal cells goes undetected. These characteristics make the telomerase an attractive target for chemotherapy.


Subject(s)
Humans , Azacitidine , Telomerase , Neoplasms , Neoplasm Proteins/physiology , Azacitidine , Tumor Cells, Cultured , Drug Design , Cellular Senescence , Telomerase , Neoplasms , Antimetabolites, Antineoplastic/pharmacology , Antimetabolites, Antineoplastic/therapeutic use , Drug Screening Assays, Antitumor , Enzyme Induction , Enzyme Inhibitors/pharmacology , Enzyme Inhibitors/therapeutic use , Biomarkers, Tumor , Neoplasm Proteins/antagonists & inhibitors , Neoplasm Proteins/chemistry , Neoplasm Proteins/genetics , Gene Expression Regulation, Neoplastic , Telomere/metabolism , Genetic Therapy
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